Warburg Effect and Mitochondrial Regulation- 2.1.3

Leaders in Pharmaceutical Business Intelligence (LPBI) Group

Warburg Effect and Mitochondrial Regulation -2.1.3

Larry H Bernstein, MD, FCAP, Writer and Curator

http://pharmaceuticalinnovation.com/2015/04/01/larryhbern/Warburg_Effect_and_Mitochondrial_Regulation

 2.1.3 Warburg Effect and Mitochondrial Regulation

2.1.3.1 Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier

NM Vacanti, AS Divakaruni, CR Green, SJ Parker, RR Henry, TP Ciaraldi, et a..
Molec Cell 6 Nov 2014; 56(3):425–435
http://dx.doi.org/10.1016/j.molcel.2014.09.024

Highlights

  • Oxidation of fatty acids and amino acids is increased upon MPC inhibition
    •Respiration, proliferation, and biosynthesis are maintained when MPC is inhibited
    •Glutaminolytic flux supports lipogenesis in the absence of MPC
    •MPC inhibition is distinct from hypoxia or complex I inhibition

Summary

Pyruvate lies at a central biochemical node connecting carbohydrate, amino acid, and fatty acid metabolism, and the regulation of pyruvate flux into mitochondria represents a critical step in intermediary metabolism impacting numerous diseases. To characterize changes in mitochondrial substrate utilization in the context of compromised mitochondrial pyruvate transport, we applied 13C metabolic flux analysis (MFA)…

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